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Phase 2 Side-Effect Frequencies at 4.5 mg/week (Lancet 2021) Side Effect Nausea Incidence at 4.5 mg/week 47% Side Effect Injection-site reactions Incidence at 4.5 mg/week 43% Side Effect Constipation Incidence at 4.5 mg/week 21% Side Effect Fatigue Incidence at 4.5 mg/week 20% Side Effect Allergic reactions (any) Incidence at 4.5 mg/week 10% Side Effect Vomiting Incidence at 4.5 mg/week 8% Side Effect Loose stools Incidence at 4.5 mg/week 7% Side Effect Headache Incidence at 4.5 mg/week 7% Side Effect Indigestion Incidence at 4.5 mg/week 4% Incidence was lower at lower doses

Results: The study included 25,451 paired images from 1,055 patients (633 in the derivation dataset and 422 in the external dataset)

Amylin and incretin peptides both participate in endocrine communication between pancreatic, gastrointestinal, and central nervous system pathways that regulate nutrient sensing and energy balance in experimental models

Patients often notice gradual but meaningful improvementsless bloating, fewer flare-ups, and improved digestive comfort

Subcutaneous B12 injections are given under the skin, typically in the abdomen or outer thigh